Pomelos and Seville oranges, a type of bitter orange often used to make marmalades and compotes, may have a similar effect. Researchers are identifying other foods that also may interact with medications, so check with your doctor or pharmacist if you have any concerns.
In 1989 a pharmacological study evaluated the possibility of an interaction between ethanol ingestion and medication with the dihydropyridine calcium channel blocker - felodipine. Grapefruit juice was used as a flavouring additive during the test. The results of study showed several-fold increase of felodipine concentrations compared to results obtained in other investigations of the drug. Additionally, there were lower blood pressure readings and more adverse effects compared to the group of subjects on felodipine alone. Further investigations revealed that grapefruit juice strikingly elevated felodipine bioavailability and could influence its other pharmacokinetic and pharmacodynamic properties.
|Drug class||Major Interactions||Minor interactions|
|Calcium channel antagonists||Plendil |
|Statins (HMG-CoA reductase inhibitors)||Mevacor (Lovastatin)||Lipitor |
Baycol (off the market)
|Immunosuppressants||Sandimmune (Cyclosporine) |
|Sedatives, hypnotics, and anxiolytics||Buspar||Halcion |
|Other psychotropics||Tegretol (Carbamazepine) |
|Antihistamines||Seldane (off the market) |
Hismanal (off the market)
|HIV protease inhibitors||Invirase |
|Hormones||Ortho-Cept (Ethinyl estradiol) |